Our Grand Chapter started as the little sisters of the Omega Delta Phi Fraternity at Nassau Community College in the summer of 1992, the little sisters broke apart from Omega Delta Phi to start their own sorority.

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The Alpha Chapter was started in 1997 at The New York Institute of Technology in Islip and remains in contact with the Stony Brook Beta Chapter.​

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The Beta Chapter of Sigma Iota Sigma was founded on November 17, 2000 at Stony Brook University to give women a better option in Greek life. Their main goal was to form a sorority that would offer women the opportunity to experience a sisterhood unlike any other.